Limitation of experimental myocardial infarct size by magnesium sulfate pre-treatment in dogs.
نویسندگان
چکیده
The present study was designed to evaluate the ability of magnesium sulfate (30 mg/kg, iv, 24 hr and 2 hr prior) to limit myocardial infarct size following permanent left coronary artery occlusion in adult mongrel dogs. Non-perfused myocardium which is the area at risk was visualised by injecting methylene blue intraatrially, 24 hr after coronary artery occlusion. The infarcted myocardium was visualised by triphenyl tetrazolium chloride staining. Infarct size (expressed as % of the risk zone) was significantly reduced in the treatment group (P less than 0.001). We conclude that magnesium sulfate exerted a potent prophylactic effect in limiting the infarct size in the dogs with permanent coronary artery occlusion.
منابع مشابه
Synergestic effect of coenzyme Q10 and magnesium sulphate in reducing myocardial infarction caused by isoproterenol in rats
The objective of the study aims to evaluate the combined protective effects of coenzyme Q10 and magnesium sulphate on isoproterenol induced myocardial damage in rats. CoenzymeQ10 (50 mg/kg) and magnesium sulphate (10 mg/kg) were administered orally to wistar rats in individual or in combination for 30 days. At the end of this period, rats were administered isoproterenol (85 mg/kg i.p.) intrape...
متن کاملCardioprotective effects of magnesium sulfate in patients undergoing primary coronary angioplasty for acute myocardial infarction.
BACKGROUND Experimental evidence indicates that magnesium sulfate may have potential cardioprotective properties as an adjunct to coronary reperfusion. The present study was designed to examine the hypothesis that magnesium might have beneficial effects on left ventricular (LV) function and coronary microvascular function in patients with acute myocardial infarction (AMI). METHODS AND RESULTS...
متن کاملEffects of pretreatment with non hypotensive dose of ramiprilat and losartan on myocardial ischemia-reperfusion induced arrhythmias and infarct size in rats
Introduction: Inhibition of renin angiotensin system represents an important approach in the management of cardiovascular diseases. The aim of this study was to explore the effects of pretreatment with non-hypotensive dose of angiotensin converting enzyme (ACE) inhibitor, ramiprilat and angiotensin type 1 (AT1) receptor blocker, losartan on myocardial infarct size and arrhythmias in a rat mo...
متن کاملIntravenous magnesium reduces infarct size after ischemia/reperfusion injury combined with a thrombogenic lesion in the left anterior descending artery.
Experimental studies have demonstrated that intravenous magnesium (Mg) can protect the ischemic myocardium and has an antithrombotic effect. In patients with myocardial infarction, the reperfusion injury is complicated by the presence of a thrombogenic area in the affected coronary artery that may cause repetitive thrombus formation and embolization. We investigated the effect of Mg on infarct ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Indian journal of physiology and pharmacology
دوره 34 3 شماره
صفحات -
تاریخ انتشار 1990